下書き　うつ病勉強会#75　Promising targets to treat depression validated in human and rodent studies.

Promising targets to treat depression validated in human and rodent studies.

Target	Human studies	Rat/mice studies
Neuronal/synaptic remodeling
BDNF	Pezawas et al., 2004; Szesko et al., 2005; Bueller et al., 2006	Berton et al., 2006; Chen et al., 2006; Aznar et al., 2010; Magarinos et al., 2011
p11	Svenningsson et al., 2006; Su et al., 2009; Zhang et al., 2011a	Svenningsson et al., 2006; Alexander et al., 2010; Warner-Schmidt et al., 2010
REDD1	Ota et al., 2014	Ota et al., 2014
Rac1	Golden et al., 2013	Golden et al., 2013
IKK	Sun et al., 2001; Pace et al., 2006 2012	LaPlant et al., 2009; Russo et al., 2009; Christoffel et al., 2011a; 2012
Transcription/epigenetics
ΔFosB	Vialou et al., 2010a	Perrotti et al., 2004; Wallace et al., 2008; Vialou et al., 2010a; 2010b; 2014; Hinwood et al., 2011; Donahue et al., 2014
β-catenin/microRNA	Saus et al., 2010; Xu et al., 2010; Karege et al., 2012	Dias et al., 2014
Histone modifications	Covington et al., 2009; Hobara et al., 2010; Non et al., 2014	Tsankova et al., 2004; 2006; Weaver et al., 2004; LaPlant et al., 2010; Bagot et al. 2012b
Immune system/inflammation
Cytokines	Maes et al., 1992; 1997; 2011; Lanquillon et al., 2000; Dean et al., 2010; Dowlati et al., 2010; Fagundes et al., 2013	Sluzewska et al., 1995; Grippo et al., 2005; Khairova et al., 2009; Kubera et al., 2011; Wohleb et al., 2011, Voorhees et al., 2013; Hodes et al., 2014
Microglia	Steiner et al., 2008; 2011; Setiawan et al., 2015	Blandino et al., 2006; 2009; Frank et al., 2007; Tynan et al., 2010; Wohleb et al., 2011; Hinwood et al., 2013
BBB permeability and monocyte infiltration	Gudmundsson et al., 2007; Bechter et al., 2010	Wohleb et al., 2012; 2013; 2014a
Astrocytes
VEGF	Arnold et al., 2012; Clark-Raymond & Halaris, 2013; Fornaro et al., 2013	Warner-Schmidt & Duman, 2007; Segi-Nishida et al., 2008
Neuronal function		Sun et al., 2012; Cao et al., 2013; Cui et al., 2014

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664582/pdf/nihms696133.pdf

共有: