下書き うつ病勉強会#75 Promising targets to treat depression validated in human and rodent studies.

Promising targets to treat depression validated in human and rodent studies.

TargetHuman studiesRat/mice studies
Neuronal/synaptic remodeling
  BDNFPezawas et al., 2004; Szesko et al., 2005; Bueller et al., 2006Berton et al., 2006Chen et al., 2006Aznar et al., 2010Magarinos et al., 2011
  p11Svenningsson et al., 2006Su et al., 2009Zhang et al., 2011aSvenningsson et al., 2006Alexander et al., 2010Warner-Schmidt et al., 2010
  REDD1Ota et al., 2014Ota et al., 2014
  Rac1Golden et al., 2013Golden et al., 2013
  IKKSun et al., 2001Pace et al., 2006 2012LaPlant et al., 2009Russo et al., 2009Christoffel et al., 2011a2012
Transcription/epigenetics
  ΔFosBVialou et al., 2010aPerrotti et al., 2004Wallace et al., 2008Vialou et al., 2010a2010b2014Hinwood et al., 2011; Donahue et al., 2014
  β-catenin/microRNASaus et al., 2010Xu et al., 2010Karege et al., 2012Dias et al., 2014
  Histone modificationsCovington et al., 2009Hobara et al., 2010Non et al., 2014Tsankova et al., 20042006Weaver et al., 2004LaPlant et al., 2010Bagot et al. 2012b
Immune system/inflammation
  CytokinesMaes et al., 199219972011Lanquillon et al., 2000Dean et al., 2010Dowlati et al., 2010Fagundes et al., 2013Sluzewska et al., 1995; Grippo et al., 2005; Khairova et al., 2009Kubera et al., 2011Wohleb et al., 2011Voorhees et al., 2013Hodes et al., 2014
  MicrogliaSteiner et al., 20082011Setiawan et al., 2015Blandino et al., 20062009Frank et al., 2007Tynan et al., 2010Wohleb et al., 2011Hinwood et al., 2013
  BBB permeability and monocyte infiltrationGudmundsson et al., 2007Bechter et al., 2010Wohleb et al., 2012; 20132014a
Astrocytes
  VEGFArnold et al., 2012Clark-Raymond & Halaris, 2013Fornaro et al., 2013Warner-Schmidt & Duman, 2007Segi-Nishida et al., 2008
  Neuronal functionSun et al., 2012Cao et al., 2013Cui et al., 2014
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664582/pdf/nihms696133.pdf